Tacoma, Washington, high school junior Aislyn's extreme shyness has crippled her socially and cost her a college scholarship, so she jumps at the chance to try an illegal gene therapy, but although she is finally able to date her long-term crush, Jack, the therapy becomes a contagious disease that can be fatal.

Industrious high school senior, Vee Delmonico, has had it with living life on the sidelines. When pressured by friends to join the popular online game Nerve, Vee decides to sign up for just one dare in what seems like harmless fun. But as she finds herself caught up in the thrill of the adrenaline-fueled competition partnered with a mysterious stranger, the game begins to take a sinister turn with increasingly dangerous acts, leading her into a high-stakes...