Sam and Dean Winchester seek out the person or force responsible for their mother's death and their father's disappearance while investigating strange occurrences across America.

After enduring unspeakable torture, Dean escapes from Hell, rescued by an angel who recruits Sam and Dean into Heaven's battle against Hell for the future of humankind. Amid whispers that a certain Fallen Angel will soon be freed from his prison deep in Hell. If Sam and Dean can't stop Lucifer from walking free, he'll bring on the Apocalypse. Meanwhile, the Winchester brothers reunite and hit the road, battling the supernatural wherever they go. They...