Dr. Helen Magnus (Amanda Tapping) is a beautiful and enigmatic scientist who seeks out all manner of monstrous creatures. Aided by forensic psychiatrist Dr. Will Zimmerman (Robin Dunne), tech expert Henry Foss (Ryan Robbins), professional con artist Kate Freelander (Agam Darshi), and the mysterious and unpredictable John Druitt (Christopher Heyerdahl), the Sanctuary team tracks down, studies and protects the strange and often terrifying creatures...

Isabel Sullivan has just moved to a small town to live with her uncle Paul who is the town's mayor. Isabel has recently lost her parents in a car accident. Feeling very alone and friendless, Isabel befriends a stray robot dog named ARCHIE. Though he looks like a normal dog, he is anything but. He can talk. He can run at blinding speed. He's got super strength and x-ray vision. Isabel and Archie become fast friends.

Archie tags along as his owner Sydney runs away to join a struggling family circus. But clumsy Sydney's only hope of stardom is a fake ventriloquist act featuring his wisecracking, woofing pal. Together, they're a hit, and the circus is saved, until a villain plots to steal the priceless dog and trade him for big bucks.

When the largest particle collider ever built suffers a catastrophic malfunction, it opens an alternate dimension and causes a series of cataclysmic events that threaten the entire human species.